The consumption of pumpkin extracts could replace insulin injections in type 1 diabetes.

Ingestion of extracts from pumpkin could allow Type I diabetics no longer having to inject insulin every day in all cases to reduce very significantly the number of injections they are obliged to face each day. This suggests that a Chinese study whose results have just been published in the Journal of the Science of Food and Agriculture.

Type I diabetes, also called “lean diabetes or” insulin dependent “, is caused by the destruction, following immune dysfunction (autoimmune disease), insulin producing cells in the pancreas.

Tao Xia and his colleagues at the Normal University East China showed that pumpkin extract would reduce the differences between diabetic rats and healthy rats. After a diet pumpkin, blood insulin levels in diabetic rats was lower by only 5% and the number of pancreatic beta cells (cells that normally synthesize insulin) fell 8%.

What magical substances are causing these effects?

The D-chiro-inositol and antioxidants, two classes of molecules would boost the level of insulin to lower blood glucose levels and reduce oxidative damage that glucose exerts normal pancreatic beta cell. Results: The cells of the pancreas are less damaged, they can regenerate and recover to make insulin, making the need less of this hormone screaming.

For David Bender, a researcher specializing in diabetes at the University Medical School in London, “these results are very exciting (…). They suggest that the pumpkin extract prevents the progressive destruction of pancreatic beta cells (…). But it is currently impossible to say whether these extracts can also regenerate human pancreatic cells.

Insulin has a key role in the process, because during the break down food digestion in order to create glucose, one of the body’s energy sources.

Glucose enters the blood, which allows insulin to enter cells. When people have diabetes that happens: either the pancreas does not produce insulin or produces too little, which is known as Type 1 Diabetes. And type 2 diabetes occurs when cells do not respond to insulin production.

In the case of type 1 diabetes is very difficult to prevent, however, in the case of type 2 diabetes can take steps to reduce the impact of the disease.

Symptoms of diabetes include chronic fatigue, sudden weight loss, nonhealing wounds, like going to urinate constantly, hungry all the time, blurred vision, sexual problems, vaginal infections, tingling in the fingertips of hands or feet, and thirst. If you think you feel some of these symptoms on a permanent basis should visit the doctor.

Type 1 diabetes occurs in young children, adolescents and young adults. Currently are still conducting research to discover what that destroys insulin-producing cells or what triggers the process and how to prevent it.

In the case of type 2 diabetes, it can be prevented. Factors contributing to the appearance of diabetes are known: age, family history of diabetes, overweight and physical inactivity.

Also this does not mean that people who lead a healthy way of life can not develop this type of diabetes.

To prevent the onset of this disease should lead a healthy life, to do you can follow these tips to help you prevent and control the onset of diabetes.

* Nutrition: a balanced diet is crucial to prevent the onset of the disease. Please include your diet foods low in fat, salt and avoid foods with added sugars. On the other hand should increase consumption of foods rich in fiber.

* Exercise: all investigations related to this disease showed that increasing the amount of exercise helps prevent disease. Only 30 minutes of exercise daily is sufficient. When you increase the amount of exercise you put to work in your metabolism, you spend more energy, and in a diabetic that means better use of insulin injected or produced by the pancreas.

The big challenge was that, until recently, scientific evidence showed that the only way of administering insulin was skin, however, found that it can be absorbed by the blood without needles or syringes, using a inhaler similar to that used in treating asthma. With the approval of this drug makes a pattern in the treatment of diabetes mellitus.

Note that you can not replace all types of insulin, it will only be used in place of the so-called regular insulin, which is that rapidly absorbed by the bloodstream, with peak action almost immediately. Do not replace basal insulin or long-term, so that some people with type 1 diabetes need to inject further, depending on the opinion of the physician.

This new insulin delivery system is one of the most important advances for treating diabetes, which help people with type 1 diabetes require daily insulin injections are many quick to maintain optimum control of their glucose levels, but it also be an excellent alternative in the treatment of people with type 2 diabetes which tells insulin treatment but refuse to use it for fear of injections.

Diabetes mellitus, commonly – Symptoms

Typical signs
The following symptoms may occur both in type 1 diabetes and type 2 diabetes:

• Frequent urination (polyuria) and nocturnal urination (nocturia)
• Increased thirst (polydipsia)
• Poor appetite and weight loss
• Fatigue, tiredness and weakness
• Food cravings, especially at the beginning of the disease
• General susceptibility to infection (especially urinary tract infections and infections of the skin)
• Itching
• Headache, dizziness
• Nausea, vomiting
• Visual disturbances
• Muscle cramps
• Loss of consciousness

In people who are not diabetic:

• the fasting and before meals is between 0.70 and 0.90 g / l
• blood sugar after meals is below 1.50 g / l.

This regulation of blood glucose is the result of insulin action on all body cells and the liver and muscles that have a particular role. Having become acquainted with each actor, we will consider the role of each.

The Type 1 diabetes affects approximately 10% of all diabetics. This form of the disease can occur at any age but most often it appears in childhood or early adulthood, hence its old name of “juvenile diabetes“.

Diabetes can develop asymptomatic manner over a long period. Individuals who have it produce very little or no insulin due to an autoimmune reaction that destroys partially or fully pancreatic beta cells. The latter role is to synthesize the hormone, which is essential to the use of blood glucose by the body as an energy source. In this type of diabetes, it is absolutely necessary to take regular insulin, hence the name often ascribed to “diabetes mellitus (IDDM).

It is not known precisely what causes the immune system to respond to beta cells. Researchers believe that genetic predisposition and factors related to the environment contribute to the development of type 1 diabetes. We know in particular that certain viruses and toxins can trigger such a reaction in people with genetic predispositions.

Extraction of bone marrow
One of the doctors removed bone marrow from the patient’s hip. This procedure takes approximately 30 minutes in total and first provided anesthesia to the puncture site and then removed with a fine needle approx. 150-200 ml of bone marrow. The injection of anesthesia can be a bit painful, extraction of bone marrow change is barely felt. Following this intervention will determine the date for implantation of bone marrow and soon the patient can go home.

Another method for the extraction of stem cells is the mobilization of stem cells from bone marrow with the help of growth factors. they are first injected into the patient, making the stem cells come from bone marrow into the blood. Then stem cells can be isolated from the blood. This method is used less frequently in XCell-Center, but in some cases may constitute an alternative to bone marrow puncture.
Isolation, analysis and concentration of stem cells in the laboratory

In the lab examines the bone marrow collected in sterile tubes in quality and quantity of stem cells it contains. This was first isolated stem cells apart, using a chromatographic procedure, the red and white blood cells and plasma. The sample is processed under sterile conditions so that the stem cells provided to the patient may become contaminated with viruses, bacteria or fungi. Additionally, before continuing with sample processing, examines that no viral markers such as HIV, hepatitis B and C and cytomegalic, if an outcome in this respect, anyway checks whether the therapy can be performed with the measures appropriate precautions. The entire process is documented and the concentrate of freshly isolated stem cells are released to the administration when they have met all quality criteria.

The purified stem cells are counted and discussed in terms of its vitality. If there are enough vital stem cells, ie more than two million CD34 positive cells with a vitality greater than 80 percent, the concentrated stem cells is able to be administered to the patient. To use the stem cells thus prepared are kept at minus 196 degrees Celsius in liquid nitrogen.

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In type I diabetics symptoms usually begin suddenly and can progress rapidly to a condition called diabetic ketoacidosis. Despite the high levels of blood sugar, most cells can not use sugar without insulin and therefore turn to other energy sources. Fat cells begin to decompose and produce ketone bodies, a toxic chemical that can cause blood acidity (ketoacidosis). Initial symptoms of diabetic ketoacidosis include excessive thirst and urination, weight loss, nausea, vomiting, exhaustion and, especially in children, abdominal pain. Breathing becomes deeper and faster because the body tries to correct the acidity of the blood. The person’s breath smells like nail polish remover. If not applied any treatment, diabetic ketoacidosis can progress and lead to coma, sometimes within hours.

Patients with type I diabetes may show the symptoms of ketoacidosis, even after starting treatment with insulin, if they miss a shot or if they suffer an infection, an accident or serious illness. Type II diabetes may not cause any symptoms for years or decades. When the insulin deficiency progresses, symptoms begin to appear. At first, increased urination and thirst are moderated, but gradually worsen over time. Ketoacidosis is a rare condition. If the concentration of blood sugar is very high (greater than 1000 mg / dl), usually by stress caused by infection or a drug, severe dehydration occurs, mental confusion, drowsiness, convulsions and a condition called hyperosmolar hyperglycemic coma nonketotic.

Key points of treatment for diabetes

The first thing to know in connection with treatment for diabetes is what the blood glucose levels. The blood glucose level is the amount of glucose you have in your blood. Glucose is a sugar contained in foods we eat and, furthermore, the body produces and stores. It is the main energy source for cells of the body and reaches every cell through the bloodstream. Glucose enters the cells with the help of a hormone called insulin.

So, how they relate to blood glucose levels with type 1 diabetes? People with type 1 diabetes produce no insulin. This means that glucose stays in the bloodstream and can not get into the cells, leading to high blood glucose levels. It is likely that a person with type 1 diabetes feel sick if you have high blood sugar levels. Therefore, the treatment plan for a person with type 1 diabetes is to keep blood sugar levels within healthy parameters, and must ensure that these people can grow and develop normally. To achieve this goal, people with type 1 diabetes must address the following:

* Insulin or use an insulin pump every day
* Follow a healthy, balanced diet, in addition to adjusting to a diabetes meal plan
* Check your blood sugar levels several times a day
* Exercising regularly

Follow the treatment plan can help a person stay healthy, but does not imply a cure for diabetes. So far, there is no cure for diabetes. Therefore, people with type 1 diabetes need to be treated for the rest of his life. It’s good to know that respect the plan can help people feel healthy and have no health problems associated with long-term diabetes.

The main goal of treatment is to maintain glucose levels within normal ranges. Treatment depends on the type of diabetes you have. It is an illness that requires daily monitoring and strict control of blood sugar levels.

In type 1 diabetes must apply the insulin that the body can not produce (there are synthetic insulins), we need people with this type of diabetes monitor their glucose levels continuously and exercise daily.

The treatment of type 2 diabetes primarily includes changes in diet, regular exercise and weight control. If these measures, which together are called changes in lifestyle are not enough, your doctor may prescribe medication to lower blood glucose levels.

If untreated, diabetes can cause:
* High blood sugar levels that can make a person feel thirst, fatigue, weight loss, frequent urination or frequent infections.
* Other serious health problems: damage to other organs, especially eyes, kidneys, nerves and heart.

People with diabetes may also have decreased levels of sugar due to: excess of drugs that lower blood sugar, excessive dose of insulin or do not eat enough. It is important to follow the pattern of food and medicines your doctor prescribes. A significant decrease in blood sugar levels can make people have tremors, dizziness, sweating, hunger, headache, pale skin, moodiness or behavior changes, difficulty paying attention, confusion and tingling in the mouth .

The best way to control diabetes is to have your blood sugar levels within normal parameters. Remember, blood sugar levels rise after eating any food, so it is very important to monitor very closely the meal plan.

Complications
* Renal (kidney)
* Cardiovascular disease (heart)
* Blindness
* Nerve damage
* Amputation
* Decreased life expectancy
* Death